Music Activity, Biofeedback sensors and Artificial Intelligence = Window to Cognitive Health.
Music, notably piano playing, involves multiple sensory processing, comprehension, quasi-simultaneous decision making and action execution. Simply put, it is one of the best ways to evaluate brain functions and to train minds.
1) Ipsilon Cognitive Test
We are currently digitalizing our cognitive test (test launch expected in 1Q, 2019).
Non-stigmatizing, piano playing-based and fun cognitive training which also comes with cognitive assessment function, easy to implement as routine brain training activity for the elderly.
What it does: evaluate impulsiveness, learning capability based on working memories.
What inputs/ outputs it assesses: comprehension (visuo-spatial/motor encoding) and finger responses.
What advantage?: eliminates language biases. Elicit multi-sensory responses, monitoring capability of many brain regions and functionalities.
What value proposition?: compatible to research-grade biofeedback stimuli, can be combined with EEG and eye tracking.
Product availability: as an web-based app (software as service) for tablets, estimated to be commercially available in 1Q, 2019.
2) Digital Cognitive Markers = Ipsilon Cognitive Test combined with Biofeedback data analysis algorithms
We are testing machine-learning algorithms to create more reliable digital cognitive markers when biofeedback (EEG & eye tracking) devices are used together with our Ipsilon Cognitive Test (small-scale control group test expected from 1Q 2019).
Mild Cognitive Impairment (MCI); Alzheimer's Disease; Attention Deficit Hyperactivity Disorder (ADHD);
Parkinson's Disease/ Lewy Body Dementia; mTBI (concussion) and CTE (chronic traumatic encephalopathy);
Pharmaceuticals' drug R&Ds for neurodegenerative diseases
Insurance (elderly cognitive fitness for driving; quantitative dementia threshold for insurance-related products)
What it does: create user's cognitive profile in comparison to Average (control group) and illness-specific cognitive markers.
What do users get?: Individual cognitive data into a profile as well as risk assessment how close their responses are to illness-specific markers.
What does it do?: illness-specific biofeedback data into comparable patterns and thresholds by algorithms.
What is your advantage?: Cognitive responses reveal neurological and neuropsychiatric abnormalities at much earlier stage than structural abnormalities revealed by medical imaging techniques (e.g. MRI, PET). Quantitative, thus numeric thresholds can be made.
Side effect?: No. Non-invasive.
When available?: R&D planned from 1Q 2019 for a year with the partnership with another startup and Utrecht Medical Center, expected availability for further clinical trials in 1Q, 2020.
3) Ipsilon Cognitive Therapy
From experiences over 15yrs of rhythmic impacts on cognition and emotion, we help reduce anxiety with specific illnesses and help train visual attention with our rhythmic therapy (prototype available, pending further development).
What it does: help reduce anxiety of specific neurological and neuropsychiatric conditions. For average users, it helps increase visual attention.
What does it use?: rhythmic stimulation at specific frequency.
Any side effects?: No. Non-invasive.
How do you know its efficacy?: when used together with EEG, the calming effect is confirmed by users' brainwave responses.
Target conditions: PTSD, Anxieties due to neurological and neuropsychiatric conditions mentioned in product 2).
When available?: R&D pending.
Our One Pager and Investor Deck are available upon request.
One-pager can be seen at Slideshare of Yayoi Sakaki, Founder and inventor.
We are in preparation for patent filing with our models and methodologies.
We are/ have been mentored through incubators/accelerator at:
InnoLabs 2nd Open Call Accelerator through delivering partner, Norway Health Tech, November, 2018 to August, 2019)
HighTechXL accelerator, Eindhoven, The Netherlands (http://www.hightechxl.com/), September 4 to December 6, 2017
ENDuRE Project (University of Pisa, www.endureproject.eu/), May 30, 2016 to June 11, 2016
Erasmus Center for Entrepreneurship (http://ece.nl/), May 6, 2016 to July 1, 2016
key words: aging, Alzheimer's, dementia, MCI, executive function, mental performance, brainwaves, music, piano, digital therapy, sensory stimulation, cognition, cognitive wellness, mindfulness.